Table 1 Results of pathway-enrichment analyses.
KEGG pathway | p value | #miRNAs |
|---|---|---|
(a) The ten most likely canonical pathways identified after pathway-enrichment analysis of 41 miRNAs that strongly modulate APP metabolism using DIANA Tools mirPath (v3.0) | ||
Axon guidance | 4.70E–08 | 48 |
Proteoglycans in cancer | 1.82E–06 | 49 |
Hippo-signaling pathway | 4.10E–06 | 50 |
Fatty-acid biosynthesis | 8.10E–05 | 11 |
Glutamatergic synapse | 8.56E–05 | 48 |
GABAergic synapse | 1.10E–04 | 48 |
AMPK-signaling pathway | 2.20E–04 | 46 |
TGF-beta-signaling pathway | 2.50E–04 | 45 |
Thyroid hormone-signaling pathway | 3.90E–04 | 48 |
Adrenergic signaling in cardiomyocytes | 5.00E–04 | 49 |
KEGG pathway | p value | #genes |
(b) The ten most likely canonical pathways identified after pathway-enrichment analysis of 132 genes targeted by 41 miRNAs (see Supplementary Methods for details) | ||
Axon guidance | 0.0014 | 19 |
Ubiquitin-mediated proteolysis | 0.010 | 16 |
Circadian rhythm | 0.036 | 8 |
