Fig. 5: Modelling the coupled changes between cortical factors and cognitive domains. | Molecular Psychiatry

Fig. 5: Modelling the coupled changes between cortical factors and cognitive domains.

From: Three major dimensions of human brain cortical ageing in relation to cognitive decline across the eighth decade of life

Fig. 5

An example of a multivariate latent growth curve model assessing associations between cortical and cognitive changes. The top half of the model illustrates how the intercept and slope of a given cognitive domain is indicated by the individual intercept and slope of multiple individual cognitive tests, tested on three occasions. The bottom half of the model illustrates how the three factors of cortical change are differentially indicated by the individual slopes of each of 34 cortical regions of interest (ROI). Residual correlations among manifest variables are not shown. ROI intercept factors were freely estimated and allowed to correlate with all latent factors (not shown to reduce figure complexity). Red paths denote associations of interest, between cognitive and cortical changes. The two secondary factors of cortical volume (F1 and F2) are orthogonal to the general slope of cortical volume, and negatively correlated with each other (r = −0.254, p < 0.001).

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