Table 1 Sample demographics for the twelve studies by the ENIGMA Consortium into structural brain alterations in neuropsychiatric disorders.

Disorder	MRI measure	Cases (n)	Controls (n)	Total n	Sites	Weighted mean age (cases)	Weighted mean age (controls)	References
ADHD	Cortical thickness	2246	1934	4180	36	19.2	18.1	[2, 28]
	Surface area	2246	1934	4180	36	19.2	18.1
	Subcortical volume	1713	1529	3242	23	18.6
ASD	Cortical thickness	1571	1651	3222	49	15.4		[18]
	Surface area
	Subcortical volume
BD	Cortical thickness	1837	2582	4419	28	38.4^a	35.6^a	[19, 30]
	Surface area	1820	2582	4402	28	38.4^a	35.6^a
	Subcortical volume	1710	2594	4304	20	40.1^a	36.5^a
Epilepsy	Cortical thickness	2149	1727	3876	24	34.4	33.3	[7]
	Surface area
	Subcortical volume
MDD	Cortical thickness	1911	7663	9574	20	44.8^a	54.6^a	[6, 22]
	Surface area	1902	7658	9560	20	44.8^a	54.6^a
	Subcortical volume	1728	7199	8927	15	43.3^a	56^a
OCD	Cortical thickness	1498	1435	2933	27	32.1	30.5	[26, 41]
	Surface area	1497	1433	2930	27	32.1	30.5
	Subcortical volume	1495	1472	2967	25	32.0	30.6
SCZ	Cortical thickness	4474	5098	9572	39	32.3^a	34.5^a	[27, 34]
	Surface area	4434	5073	9507	39	32.3^a	34.5^a
	Subcortical volume	2028	2540	4568	15	34.0^a	31.0^a

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