Fig. 3: Selective deletion of AdipoR1 in 5-HT neurons induces depression-related behaviors.
From: Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons
a Female urine sniffing test, AdipoR1f/f, n = 12; AdipoR1f/f;ePet-Cre, n = 11. b Sucrose preference test. Left, male mice, AdipoR1f/f, n = 12; AdipoR1f/f;ePet-Cre, n = 11. Right, female mice, AdipoR1f/f, n = 11; AdipoR1f/f;ePet-Cre, n = 14. c Saccharin preference test. Left, male mice, AdipoR1f/f n = 12; AdipoR1f/f;ePet-Cre, n = 11. Right, female mice, AdipoR1f/f, n = 11; AdipoR1f/f;ePet-Cre, n = 14. d Forced swim test. Left, male mice, AdipoR1f/f, n = 12; AdipoR1f/f;ePet-Cre, n = 10. Right, female mice, AdipoR1f/f, n = 11; AdipoR1f/f;ePet-Cre, n = 14. e Locomotor activity. The time course of locomotor activity of male (left) and female (right) mice. The inserts indicating the total distance traveled during the 30-min test. Male mice, AdipoR1f/f, n = 12; AdipoR1f/f;ePet-Cre, n = 11. Female mice, AdipoR1f/f, n = 11; AdipoR1f/f;ePet-Cre, n = 14. f (Left and middle-left) Sucrose preference test performed on mice after 5-day CUS. Male mice: AdipoR1f/f, n = 8; AdipoR1f/f;ePet-Cre, n = 8. Female mice: AdipoR1f/f, n = 11; AdipoR1f/f;ePet-Cre, n = 12. (Middle-right and right) Forced swim test. Male mice: AdipoR1f/f, n = 8; AdipoR1f/f;ePet-Cre, n = 8. Female mice: AdipoR1f/f, n = 11; AdipoR1f/f;ePet-Cre, n = 12. g Elevated plus-maze test performed on male (left panel) and female (right panel) mice. Male mice: AdipoR1f/f, n = 10; AdipoR1f/f;ePet-Cre, n = 9. Female mice: AdipoR1f/f, n = 9; AdipoR1f/f;ePet-Cre, n = 9. h Open-field test performed on male (left panel) and female (right panel) mice. Male mice: AdipoR1f/f, n = 10; AdipoR1f/f;ePet-Cre, n = 9. Female mice: AdipoR1f/f, n = 10; AdipoR1f/f;ePet-Cre, n = 8. *P < 0.05, **P < 0.01 compared with AdipoR1f/f littermate controls.
