Fig. 2: Inducers/boosters of serum NMDAR1-AB. | Molecular Psychiatry

Fig. 2: Inducers/boosters of serum NMDAR1-AB.

From: Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury

Fig. 2: Inducers/boosters of serum NMDAR1-AB.The alternative text for this image may have been generated using AI.

a Experimental outline of the cryolesion experiment (cryolesion according to Sirén et al. [29]). b Higher Ig-class diversity of serum NMDAR1-AB at 4 months after cryolesion versus sham operation. c Increased percentage of serum NMDAR1-AB upon cryolesion is due to IgG and IgM. N numbers/percentage displayed in bars; chi-square test (IgA, IgM, and IgG + IgM) or Fisher’s exact test (IgG), two sided. d Human CTLA4 SNPs predispose to serum NMDAR1-AB (IgA + IgG) as seen in both allelic and genotypic analyses (minor variation in N numbers due to missing information). e Experimental outline of CTLA4-AB treatment of mice. f CTLA4-AB validation by flow cytometry on cells from murine lymph nodes (FACS): left, control staining (without CTLA4-AB), right, CTLA4-AB staining; cells pre-gated on CD4+. g Representative images of FoxP3 ± CTLA4-AB staining of murine spleen cells, demonstrating specific double labeling of regulatory T-cells. h Intraindividual follow-up of NMDAR1-AB seropositivity upon CTLA4-AB versus isotype-control IgG treatment. N numbers displayed in bars; Cochran–Armitage test for trend or chi-square test, two sided.

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