Fig. 2: Cutaneous gene delivery of GLP1 decreases alcohol-induced DA accumulation in the NAc. | Molecular Psychiatry

Fig. 2: Cutaneous gene delivery of GLP1 decreases alcohol-induced DA accumulation in the NAc.

From: Reducing alcohol and/or cocaine-induced reward and toxicity via an epidermal stem cell-based gene delivery platform

Fig. 2

a DA levels in the NAc following i.p. injections of 1 g/kg alcohol in GGLP1 and GWT mice (n = 5 per group; treatment × time interaction: F4,32 = 7.928, P = 0.0001 by repeated-measures ANOVA). Significance was tested by Fisher’s LSD test. *P = 0.0161 between GLP1 and GWT mice 30 min after injection. b Alcohol concentration in plasma. This was quantified by using ELISA following acute i.p. injections of 1 g/kg alcohol in GGLP1 and GWT mice (n = 6 per group; treatment × time interaction: F4,40 = 0.1178, P = 0.9754 by repeated-measures ANOVA).

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