Fig. 1: MRs and DMRs in BD. | Molecular Psychiatry

Fig. 1: MRs and DMRs in BD.

From: Decreased DNA methylation at promoters and gene-specific neuronal hypermethylation in the prefrontal cortex of patients with bipolar disorder

Fig. 1

a PCA of the MRs of each sample and the effect of age and PMI. Spearman’s rank correlation coefficient and P value are given. Pink and blue colors indicate neurons and nonneurons, respectively. b Decreased number of MRs in BD. An asterisk (*) shows significant changes by the Mann–Whitney test. c Effect of age onset, duration of illness, and lifetime antipsychotics on MRs in BD. Lifetime antipsychotics are given in fluphenazine equivalents. One patient with excess lifetime antipsychotics was removed from the plot. The presence or absence of this subject did not affect statistical values. d Chromosomal locations of DMRs. DMRs on autosomes are presented [65]. e Total number of DMRs and DMR-associated genes. f Venn diagrams of DMR-associated genes. MR methylated region, DMR differentially methylated region, PCA principal component analysis, PMI postmortem interval, CT control, BD bipolar disorder.

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