Fig. 5: Lactate, β-hydroxybutyrate, and NADH partially counteract the decreased proliferation of adult hippocampal stem/progenitor cells induced by corticosterone in vitro.
From: Role of adult hippocampal neurogenesis in the antidepressant actions of lactate
Analysis of stem/progenitor cell proliferation. Cultures of adult hippocampal stem/progenitor cells were treated for 48 h with corticosterone (5 μM) together with either lactate (20 mM) (a), pyruvate (20 mM) (a), β-hydroxybutyrate (20 mM) (b), acetoacetate (20 mM) (b) or NADH (100 μM) (c). Left panels: histograms of the number of BrdU+ cells presented as a percentage of the vehicle. Right panels: fluorescent images of stem/progenitor cells immunostained for BrdU. Data are the mean ± SEM. One-way ANOVA followed by Tukey post-hoc test (n > 16/condition). *p < 0.05.
