Fig. 5: Timecourse of memory improvements after SUSonly treatment and integrated model of the effects of SUS on the aging brain. | Molecular Psychiatry

Fig. 5: Timecourse of memory improvements after SUSonly treatment and integrated model of the effects of SUS on the aging brain.

From: Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling

Fig. 5

A Comparing the change in the maximum time animals can avoid the shock zone as a measure of the learning ability during APA reveals a trend toward increased ability after one (SingleSUS, n = 8) and three SUSonly treatments (TripleSUS, n = 8), which after six SUSonly sessions (SUSonly, n = 20) becomes significant (one-way ANOVA [F(5,70) = 3.879, p = 0.0037] with Bonferroni post hoc analysis). B Integrated model differentiating A-type effects of SUS due to a pressure wave (SUSonly) and B-type effects, adding modulatory effects due to BBB opening and the uptake of blood-borne factors by the brain (SUS+MB). The acoustic forces from SUS alter the hippocampal milieu by reducing the ECM, increasing neurogenesis and altering the activity and proteomic profile of hippocampal proteins. These changes ultimately result in improved functional outcomes including reinstatement to induce LTP and improved spatial learning. Scoring (pluses and minuses) indicates the corresponding effect for the respective read-outs.

Back to article page