Table 1 Main variables of interest in the two cohorts.
UK Biobank | NESDA | |
|---|---|---|
N = 143,465 | N = 2,905 | |
Sociodemographics | ||
Age years (mean ± SD) | 55.9 (7.7) | 41.9 (13.1) |
Sex (F) (%) | 56.2 | 66.5 |
Symptom endorsement - Depression (%) | ||
D.1 Anhedonia | 18.5 | 13.9 |
D.2 Depressed mood | 21.9 | 21.6 |
D.3 Sleep problem | 48.7 | 25.9 |
D.4 Fatigues | 49.9 | 36.5 |
D.5 Appetite change | 18.2 | 7.7 |
D.6 Feelings of inadequacy | 19.2 | 24.2 |
D.7 Cognitive problems | 17.9 | 21.9 |
D.8 Psychomotor change | 5.5 | 18.1 |
D.9 Suicidal ideation | 4.3 | 12.2 |
Symptom summary scales | ||
Psychological symptoms (mean ± SD) | 0.74 (1.51) | 0.721 (1.04) |
Somatic symptoms (mean ± SD) | 1.65 (2.03) | 1.09 (1.30) |
Symptom endorsement - Anxiety (%) | ||
A.1 Anxiety | 28.0 | 24.5 |
A.2 Worrying control | 23.4 | 24.8 |
A.3 Generalised worrying | 31.6 | 31.5 |
A.4 Lack of relaxation | 28.3 | 32.3 |
A.5 Restlessness | 11.8 | 25.7 |
A.6 Irritability | 27.2 | 21.0 |
A.7 Foreboding | 16.6 | 20.4 |
Inflammatory markers | ||
CRP (mg/L) (median, IQR) | 1.15 (0.58–2.37) | 1.22 (054–3.00) |
IL-6 (pg/mL) (median, IQR) | NA | 0.75 (0.49–1.25) |
