Table 2 Pooled association results between CRP and depressive/anxiety symptoms.

From: Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts

  

Model 1

  

Model 2

  

Model 3

 

Symptom

OR (95% CI)

P

Q

OR (95% CI)

P

Q

OR (95% CI)

P

Q

Depressive symptoms

         

Anhedonia

1.13 (1.03–1.23)

0.01

0.02

1.08 (0.99–1.18)

0.101

0.203

1.03 (0.96–1.11)

0.423

0.789

Depressed mood

1.1 (1.07–1.13)

<0.001

<0.001

1.06 (1.05–1.08)

<0.001

<0.001

1.03 (1.01–1.04)

<0.001

0.002

Sleeping problems

1.07 (1.06–1.08)

<0.001

<0.001

1.05 (1.04–1.06)

<0.001

<0.001

1.02 (1.01–1.03)

<0.001

0.003

Fatigue

1.17 (1.15–1.18)

<0.001

<0.001

1.12 (1.11–1.14)

<0.001

<0.001

1.06 (1.05–1.07)

<0.001

<0.001

Appetite changes

1.3 (1.2–1.4)

<0.001

<0.001

1.25 (1.23–1.28)

<0.001

<0.001

1.02 (0.96–1.1)

0.499

0.789

Feelings of inadequacy

1.02 (0.91–1.14)

0.734

0.777

1 (0.9–1.1)

0.925

0.979

0.98 (0.92–1.05)

0.564

0.789

Cognitive problems

1.08 (1.01–1.16)

0.034

0.055

1.05 (0.99–1.11)

0.092

0.203

1.02 (1–1.03)

0.043

0.128

Psychomotor changes

1.07 (0.87–1.3)

0.537

0.644

1.03 (0.86–1.22)

0.778

0.875

0.99 (0.86–1.13)

0.859

0.859

Suicidal ideation

1.04 (0.86–1.26)

0.683

0.768

1 (0.86–1.17)

0.991

0.991

0.99 (0.91–1.09)

0.856

0.859

Anxiety symptoms

         

Anxiety

1.01 (1–1.03)

0.012

0.022

1 (0.99–1.01)

0.758

0.875

1 (0.99–1.02)

0.606

0.789

Worrying control

1.05 (1.03–1.08)

<0.001

<0.001

1.03 (1.02–1.04)

<0.001

<0.001

1.01 (1–1.03)

0.033

0.12

Generalised worrying

1.03 (1.01–1.04)

<0.001

<0.001

1.01 (0.99–1.02)

0.309

0.505

1 (0.99–1.01)

0.833

0.859

Lack of relaxation

1.04 (1.02–1.05)

<0.001

<0.001

1.01 (1–1.02)

0.057

0.147

1.01 (1–1.02)

0.206

0.464

Restlessness

0.98 (0.84–1.15)

0.834

0.834

0.96 (0.85–1.1)

0.586

0.812

0.96 (0.86–1.08)

0.52

0.789

Irritability

1.09 (1.07–1.1)

<0.001

<0.001

1.06 (1.05–1.08)

<0.001

<0.001

1.03 (1.01–1.04)

<0.001

<0.001

Foreboding

1.04 (0.98–1.1)

0.21

0.29

1.01 (0.96–1.07)

0.677

0.871

1 (0.97–1.02)

0.812

0.859

Depressive symptom score

β (SE)

P

Q

β (SE)

P

Q

β (SE)

P

Q

Psychological symptoms

0.043 (0.042)

0.312

0.402

0.023 (0.029)

0.42

0.63

0.006 (0.012)

0.614

0.789

Somatic symptoms

0.14 (0.11)

0.203

0.29

0.099 (0.077)

0.2

0.36

0.041 (0.028)

0.144

0.371

  1. Estimates describe the association with the outcome per 1 unit increase in (log)CRP.
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