Fig. 1: Memory loss in aged mice, rescued by perineuronal net attenuation.
From: Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing
A OR memory deficit in aged mice. Time of delay 1 min, 6 h, 24 h. Unpaired two-tailed t-test, ***p = 0.0002. B Spontaneous alternation deficit in aged mice. A total number of arm entries 6 M vs 20 M, 22.8 ± 2.4 vs 19 ± 1.38. Spontaneous alternation (%) 69.9 ± 4.3 vs 56.3 ± 3.1, unpaired two-tailed t-test, *p = 0.0392, alternate arm entry (%) 27.9 ± 4.6 vs 29.7 ± 3.1. Same arm return (%) 1.05 ± 1.05 vs 7.76 ± 2.98. C Marble burying test in C57bl/6 at different ages, left: representative images of marble-burying test right: 4 M n = 10, 7 M n = 7, 20 M n = 11, One-way ANOVA **p = 0.004, Tukey post hoc test, 4 M vs 12 M *p < 0.05, 4 M vs 20 M *p < 0.05, 7 M vs 12 M *p < 0.05, Data represents as mean ± SEM. D SOR memory in aged hapln1 KO mice (two separate experiments). Unpaired two-tailed t-test. 6 h delay: *p = 0.0094. Twenty-four hours: *p = 0.032, *p = 0.0226. Forty-eight hours delay: *p = 0.0145.
