Fig. 2: Chondroitinase ABC treatment restores memory and Parvalbumin levels.
From: Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing
A Timeline of ChABC treatment to young and aged mice. B ChABC injection rescued age-related OR memory deficit. 6 h memory at 20 M, unpaired two-tailed t-test, ***p = 0.0001. Twenty-four hours memory at 6 M, unpaired two-tailed t-test, **p = 0.0074. Wash-out of ChABC treatment effect of 6 h memory in 20 M mice. 2-Way ANOVA interaction treatment × time, ***p < 0.001. Main effect of Time: **p < 0.01. Treatment: **p < 0.01. Bonferroni posthoc test, ChABC 2 weeks vs 6 weeks, ***p < 0.001. Two weeks Pnase vs ChABC, ***p = 0.0002. C PV network in aged mice. 6 M vs 20 M low PV: **p = 0.0012, high PV **p = 0.0061, n = 6/group. Data present as mean ± SEM. D PV network modification after ChABC treatment in 6 M vs 20 M old mice 6 M Pnase vs ChABC n = 6/group, low: ***p < 0.0001 medium: **p = 0.0027 high: **p = 0.0028, 20 M Pnase vs ChABC n = 4/group, low: *p = 0.019 High: **p = 0.0099. E Representative images of the staining profiles of WFA (green), PV (magenta) and DAPI (blue) in 20 M old mice after Pnase and ChABC treatment. Scale bar: 50 µm.
