Fig. 5: Restoration of C6S affects PV levels and inhibitory synapses.
From: Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing
A PV and WFA network in AAV-chst3 injected aged mice (a) PV network. High: ***p = 0.0001. Low: n.s. p = 0.079. (b) WFA network. High: ***p < 0.0001. Low: **p = 0.0016. B (a), (b) chst3 increased the inhibitory synapses on PV neurons in aged mice. (a) n = 6/group. 6 M vs 20 M ***p = 0.0002. 20 M vs 20M-chst3, *p = 0.01. Unpaired two-tailed t-test. (b) Staining profiles of gephyrin (+) synaptic puncta on PV cells. B (c) Correlation profiles between numbers of gephyrin synaptic puncta and PV intensity. 20 M: correlation *p = 0.0186, Spearman r = −0.3576, 20M-Chst3: Correlation ***p = 0.0003, Spearman r = −0.4717, 6 M: Correlation *p = 0.0364, Spearman r = −0.2686.
