Fig. 1: Cocaine-induced locomotor mono- and cross-sensitization.
From: Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity
A, B Schematic of protocols used to induce locomotor sensitization and testing environment. Two cocaine injections (15 mg/kg, i.p.) separated by 7 days abstinence were used to induced locomotor sensitization (Mono-sens). A single cocaine injection (15 mg/kg, i.p.) after 7d discontinuation from chronic haloperidol (i.e., 14 days pretreatment) was used to induce locomotor sensitization (Cross-sens). C Mono-sensitized and cross-sensitized mice exhibited enhanced locomotion relative to saline-treated mice (two-way ANOVA Time × Treatment F(24,320) = 11.68, p < 0.0001, ****p < 0.0001 vs Saline using Tukey’s test). Animal N shown in legend.
