Fig. 7: The vHPC and its projections to the septum were excited under anxiogenic environments.
From: Activation of septal OXTr neurons induces anxiety- but not depressive-like behaviors
a A schematic illustration of targeting a vector carrying GCaMP6s to the vHPC and implanting a wireless TeleFipho fiber cannula over the targeted site. b A representative trace of real-time wireless photometry monitoring of vHPC GCaMP6s signals in light and dark chambers of the light-dark box (LDB). c, d Group data of normalized GCaMP6s signals recorded in (c) LDB and (d) elevated plus-maze (EPM) tests. e An illustration of targeting a vector carrying axon-GCaMP6s to the vHPC and implanting a wireless photometry fiber over the LS. f A representative trace of real-time monitoring of vHPC axon GCaMP6s signals in the LS in the LDB. g, h Group data of normalized vHPC axon GCaMP6s signals in the LS recorded in (g) LDB and (h) EPM. Each dot in (c, d, g, h) represents one animal. Mean ± SEM; ****p < 0.0001; vHPC ventral hippocampus, LS lateral septum.
