Table 2 Multivariable regression models predicting the rate of cognitive decline.

From: Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults

Indep. pred.

Std. β

(95% CI)

P value

q value

R2

(AIC)

Indep. pred.

Std. β

(95% CI)

P value

q value

R2

(AIC)

 

Slope PACC5 ~ fusiform cMD + PIB-FLR + PACC5 + (fusiform CTh)

Fusiform cMD

−0.24 (−0.38 to −0.10)

8 × 10−4

0.005

0.34 (489)

Fusiform cMD

−0.17 (−0.32 to −0.03)

0.022

0.043

0.37 (484)

PIB-FLR

−0.33 (−0.45 to −0.21)

2 × 10−7

3 × 10−7

 

PIB-FLR

−0.32 (−0.44 to −0.20)

3 × 10−7

4 × 10−7

 

PACC5

0.27 (0.14 to 0.40)

9 × 10−5

1 × 10−4

 

PACC5

0.25 (0.12 to 0.38)

2 × 10−4

3 × 10−4

 
     

Fusiform CTh

0.17 (0.04 to 0.30)

0.012

0.046

 
 

Slope PACC5 ~ inferior-temporal cMD + PIB-FLR + PACC5 + (inferior-temporal CTh)

Inf. temp. cMD

−0.23 (−0.39 to −0.08)

0.003

0.005

0.34 (491)

Inf. temp. cMD

−0.20 (−0.37 to −0.03)

0.020

0.043

0.34 (492)

PIB-FLR

−0.34 (−0.47 to −0.22)

8 × 10−8

2 × 10−7

 

PIB-FLR

−0.35 (−0.47 to −0.23)

6 × 10−8

2 × 10−7

 

PACC5

0.27 (0.14 to 0.41)

6 × 10−5

1 × 10−4

 

PACC5

0.27 (0.14 to 0.40)

8 × 10−5

2 × 10−4

 
     

Inf. temp. CTh

0.06 (−0.08 to 0.19)

0.40

0.48

 
 

Slope PACC5 ~ isthmus cingulate cMD + PIB-FLR  +  PACC5  + (isthmus cingulate CTh)

Isthmus cing. cMD

−0.21 (−0.34 to −0.08)

0.001

0.005

0.34 (490)

Isthmus cing. cMD

−0.21 (−0.34 to −0.08)

0.001

0.011

0.34 (491)

PIB-FLR

−0.34 (−0.46 to −0.22)

1 × 10−7

2 × 10−7

 

PIB-FLR

−0.34 (−0.46 to −0.21)

2 × 10−7

3 × 10−7

 

PACC5

0.26 (0.13 to 0.39)

1 × 10−4

1 × 10−4

 

PACC5

0.26 (0.13 to 0.39)

2 × 10−4

2 × 10−4

 
     

Isthmus cing. CTh

0.04 (−0.09 to 0.16)

0.57

0.57

 
 

Slope PACC5 ~ lateral orbitofrontal cMD +  PIB-FLR +  PACC5 + (lateral orbitofrontal CTh)

Lateral orbitofr. cMD

−0.15 (−0.28 to −0.01)

0.034

0.039

0.32 (496)

Lateral orbitofr. cMD

−0.16 (−0.29 to −0.02)

0.027

0.044

0.32 (497)

PIB-FLR

−0.35 (−0.47 to −0.23)

6 × 10−8

2 × 10−7

 

PIB-FLR

−0.35 (−0.48 to −0.23)

6 × 10−8

2 × 10−7

 

PACC5

0.28 (0.14 to 0.41)

6 × 10−5

1 × 10−4

 

PACC5

0.28 (0.15 to 0.42)

5 × 10−5

2 × 10−4

 
     

Lateral orbitofr. CTh

−0.05 (−0.17 to 0.07)

0.42

0.48

 
 

Slope PACC5 ~ middle-temporal cMD  +  PIB-FLR +  PACC5 + (middle-temporal CTh)

Mid. temp. cMD

−0.24 (−0.39 to −0.09)

0.002

0.005

0.34 (490)

Mid. temp. cMD

−0.21 (−0.37 to −0.04)

0.016

0.043

0.34 (492)

PIB-FLR

−0.34 (−0.46 to −0.22)

1 × 10−7

2 × 10−7

 

PIB-FLR

−0.34 (−0.46 to −0.22)

1 × 10−7

2 × 10−7

 

PACC5

0.26 (0.13 to 0.40)

1 × 10−4

1 × 10−4

 

PACC5

0.26 (0.13 to 0.39)

1 × 10−4

2 × 10−4

 
     

Mid. temp. CTh

0.06 (−0.08 to 0.21)

0.37

0.48

 
  1. All models were adjusted for age, sex and education, which were all nonsignificant predictors. Multiple-comparisons corrected results are indicated by FDR q values.
  2. AIC Akaike Information Criterion, cMD cortical mean diffusivity, CTh cortical thickness, PACC5 Preclinical Alzheimer Cognitive Composite-5, PIB-FLR 11C-Pittsburgh compound-B in a cortical composite including frontal, lateral temporo-parietal, and retrosplenial regions.
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