Fig. 5: Disrupted spike sequences and ripple phase locking in Shank3-KO mice. | Molecular Psychiatry

Fig. 5: Disrupted spike sequences and ripple phase locking in Shank3-KO mice.

From: Disrupted social memory ensembles in the ventral hippocampus underlie social amnesia in autism-associated Shank3 mutant mice

Fig. 5

Pairwise similarities of unit activities during SPW-Rs (a) and their statistical significance (b; based on a permutation test). Units are sorted according to the social preferences. c Comparable online (left) and offline (right) activity similarity between pairs from WT (n = 237 pairs, 11 sessions) and KO (n = 100 pairs, 7 sessions) mice. d Correlations between online and offline activity similarity of simultaneously recorded cell pairs from WT (n = 206 pairs) and KO (n = 100 pairs) mice. e Quantitative measurement and comparison of offline similarities at different MUA threshold factors between WT and KO mice. Main effect of Genotype, F(1,304) = 9.7, P = 0.0020, η2 = 0.0043, partial η2 = 0.029; Genotype×Threshold, F(1,304) = 9.8, P = 0.0019, η2 = 0.0047, partial η2 = 0.030. ***P < 0.001, **P < 0.01, and *P < 0.05, r = 0.12–0.20, Tukey-Kramer multiple comparison test. f Correlations between the differences of mean rank orders during online theta cycles and offline ripples. g Schematic of the behavioral paradigm. h A four-shank silicon probe was implanted in the dorsal CA1 of freely moving mice. i Quantitative measurement and comparison of offline similarities at different MUA threshold factors between WT (n = 2 mice, n = 338 pairs, 4 sessions) and KO (n = 2 mice, n = 366 pairs, 4 sessions) mice. Main effect of Genotype, F(1,702) = 0.694, p = 0.41, η2 = 9.4 × 10−5, partial η2 = 9.4 × 10−4; Threshold, F(1,702) = 2244.2, P = 7.8×10−221, η2 = 0.39, partial η2 = 0.76; Genotype × Threshold, F(1,702) = 0.296, P = 0.59, η2 = 5.2 × 10−5, partial η2 = 1.0 × 10−4. j Correlations between online and offline activity similarity of simultaneously recorded cell pairs from WT (P = 1.7 × 10−4; n = 210 cells) and KO (P = 7.2 × 10−10; n = 265 cells) mice. ns, P = 0.19, permutation test. k Correlations between the differences of mean rank orders during online theta cycles and offline ripples. ns, P = 0.86, permutation test. l Schematic representation of the findings.

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