Table 1 Participant characteristics.

From: Rare variants in IFFO1, DTNB, NLRC3 and SLC22A10 associate with Alzheimer’s disease CSF profile of neuronal injury and inflammation

 

EMIF

ADNI

Characteristic

n

Mean/%

SD

n

Mean/%

SD

Age

353

71.23

8.72

127

74.42

6.11

Female

182

51.6%

 

50

39.4%

 

Education (in years)

280

10.82

3.79

127

15.94

3.13

Ancestry

 European

353

100%

121

95.3%

 African

5

3.9%

 Asian

1

0.8%

Diagnosis

 Cognitively normal

45

12.5%

62

49.6%

 Subjective cognitive impairment

22

7.10%

0

0%

 Mild cognitive impairment

185

51.7%

64

50.4%

 Alzheimer’s disease

101

28.7%

0

0%

 Mini-mental state examination

350

25.01

4.50

127

28.20

1.63

CSF biomarkers

 β-Amyloid42 (in pg/ml)

352

295.51

181.70

127

1024.60

476.99

 Tau (in pg/ml)

351

318.27

344.14

127

276.32

101.78

 Phosphorylated Tau (in pg/ml)

351

53.85

32.95

127

26.44

11.45

 Neurofilament light (in pg/ml)

352

1315.39

2394.16

127

1299.76

1174.46

 YKL-40 (in pg/ml or z-scorea)

353

176946.43

67909.97

63

0.00

0.85

 Neurogranin (in pg/ml)

345

127.44

193.41

127

425.86

282.45

  1. Demographic information and descriptive statistics.
  2. n sample size, SD standard deviation.
  3. aFor ADNI, average values of two peptide sequences, with two ion frequencies each, were averaged after z-score standardization.