Table 1 Genome-wide association results for total cerebellar volumes in UK Biobank following COJO analysis.
Locus | Cytoband | CHR | Extended-LD range | Index SNP Name | Index SNP Position | A1/A2 | BetaGWAS (SE) | PGWAS | BetaCOJO (SE) | PCOJO |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 1p34.2 | 1 | 40236396..40434968 | rs12127002 | 40384968 | A/G | −0.0334 (0.0055) | 1.53E−09 | −0.0334 (0.0055) | 1.36E−09 |
2 | 1p32.3 | 1 | 50841117..52638689 | rs7530673 | 51558856 | A/C | 0.0542 (0.0055) | 4.00E−23 | 0.0526 (0.0055) | 1.58E−21 |
2 | 1p32.3 | 1 | 50776624..51682964 | rs1278519 | 50897342 | A/C | −0.0344 (0.0055) | 4.17E−10 | −0.0318 (0.0055) | 8.74E−09 |
3 | 2p23.3 | 2 | 25479624..25619823 | rs6546070 | 25531779 | A/G | 0.0303 (0.0055) | 3.34E−08 | 0.0303 (0.0055) | 4.08E−08 |
4 | 2p11.2 | 2 | 88749514..89179064 | rs7593335 | 88878133 | A/G | 0.0345 (0.0055) | 3.07E−10 | 0.0345 (0.0055) | 4.22E−10 |
5 | 2q35 | 2 | 217673928..217980232 | rs2542212 | 217803906 | A/G | −0.0331 (0.0055) | 1.65E−09 | −0.0329 (0.0055) | 2.24E−09 |
6 | 2q36.1 | 2 | 222949007..223309955 | rs75779789 | 223057209 | A/G | 0.0338 (0.0055) | 7.42E−10 | 0.0336 (0.0055) | 1.03E−09 |
7 | 3p21.31 | 3 | 48184492..50153917 | rs7640903 | 49338465 | A/G | 0.0339 (0.0055) | 6.37E−10 | 0.0339 (0.0055) | 8.62E−10 |
8 | 4p16.2 | 4 | 4638654..4902425 | rs10033073 | 4775401 | A/G | 0.0334 (0.0055) | 1.34E−09 | 0.0334 (0.0055) | 1.50E−09 |
9 | 4q22.1 | 4 | 88611354..89316460 | rs4148155 | 89054667 | A/G | 0.0376 (0.0055) | 7.32E−12 | 0.0376 (0.0055) | 9.17E−12 |
10 | 4q24 | 4 | 102657791..103426409 | rs13135092 | 103198082 | A/G | −0.0532 (0.0055) | 3.23E−22 | −0.0532 (0.0055) | 5.57E−22 |
11 | 4q31.21 | 4 | 145330633..146224823 | rs6812830 | 145613807 | A/G | 0.0306 (0.0055) | 2.39E−08 | 0.0370 (0.0056) | 4.89E−11 |
12 | 5q14.2 | 5 | 81667102..82008326 | rs55803832 | 81920587 | A/C | −0.0383 (0.0055) | 3.09E−12 | −0.0383 (0.0055) | 4.44E−12 |
13 | 5q22.2 | 5 | 111934537..112311278 | rs3846716 | 112059594 | A/G | −0.0302 (0.0055) | 4.10E−08 | −0.0302 (0.0055) | 4.52E−08 |
14 | 5q33.3 | 5 | 158058006..158536993 | rs7380908 | 158396062 | A/C | −0.0326 (0.0055) | 2.70E−09 | −0.0326 (0.0055) | 3.41E−09 |
15 | 6p22.3 | 6 | 22006131..22184959 | rs9393227 | 22100912 | A/G | 0.0312 (0.0055) | 1.54E−08 | 0.0314 (0.0055) | 1.23E−08 |
16 | 6p22.2 | 6 | 25264597..28544225 | rs1800562 | 26093141 | A/G | −0.0377 (0.0055) | 6.75E−12 | −0.0379 (0.0055) | 5.94E-12 |
17 | 6q16.2 | 6 | 99654270..100334555 | rs546897 | 100132856 | A/G | −0.0332 (0.0055) | 1.49E−09 | −0.0331 (0.0055) | 1.95E−09 |
18 | 6q21 | 6 | 108635716..109080753 | rs1935951 | 108999101 | A/G | 0.0368 (0.0055) | 2.18E−11 | 0.0367 (0.0055) | 3.06E−11 |
19 | 6q22.32 | 6 | 126598460..127377494 | rs72971190 | 127088303 | A/G | −0.0373 (0.0055) | 1.24E−11 | −0.0373 (0.0055) | 1.46E−11 |
20 | 7q36.3 | 7 | 156100022..156273180 | rs57131976 | 156167072 | A/C | 0.0409 (0.0055) | 1.12E−13 | 0.0456 (0.0055) | 2.82E−16 |
20 | 7q36.3 | 7 | 156016471..156178006 | rs11764163 | 156066865 | A/G | 0.0336 (0.0055) | 1.12E−09 | 0.0391 (0.0055) | 2.10E−12 |
21 | 8p23.1 | 8 | 8042025..11945009 | rs2572397 | 11176403 | A/G | −0.0325 (0.0055) | 3.11E−09 | −0.0325 (0.0055) | 4.05E−09 |
22 | 8q24.3 | 8 | 141983550..142130336 | rs6984592 | 142040038 | A/G | 0.0335 (0.0055) | 9.85E−10 | 0.0335 (0.0055) | 1.35E−09 |
23 | 9q31.2 | 9 | 109365922..109976563 | rs7027172 | 109571457 | A/G | −0.0310 (0.0055) | 1.79E−08 | −0.0305 (0.0055) | 2.78E−08 |
24 | 9q33.1 | 9 | 119007741..119200439 | rs72754248 | 119061396 | A/G | 0.0683 (0.0055) | 1.08E−35 | 0.0716 (0.0055) | 3.62E−38 |
24 | 9q33.1 | 9 | 119117887..119553742 | rs17220352 | 119248059 | A/G | 0.0401 (0.0055) | 2.69E−13 | 0.0455 (0.0055) | 2.17E−16 |
25 | 9q34.11 | 9 | 131364336..132013262 | rs3118634 | 131905854 | A/G | −0.0348 (0.0055) | 2.14E−10 | −0.0348 (0.0055) | 2.65E−10 |
26 | 10q26.13 | 10 | 123306938..123606457 | rs4752582 | 123443605 | A/G | −0.0322 (0.0055) | 4.89E−09 | −0.0322 (0.0055) | 5.00E−09 |
27 | 12q23.2 | 12 | 102349379..102996220 | rs5742632 | 102856474 | A/G | −0.0530 (0.0055) | 3.90E−22 | −0.0482 (0.0055) | 5.95E−18 |
27 | 12q23.2 | 12 | 102405447..103009565 | rs703545 | 102943000 | A/G | −0.0437 (0.0055) | 2.48E−15 | −0.0377 (0.0055) | 1.24E−11 |
28 | 13q21.33 | 13 | 72807523..73006046 | rs529059 | 72933970 | A/G | −0.0308 (0.0055) | 2.38E−08 | −0.0308 (0.0055) | 2.42E−08 |
29 | 15q25.2 | 15 | 82339282..84014925 | rs62012045 | 82521707 | A/G | 0.0315 (0.0055) | 9.79E−09 | 0.0315 (0.0055) | 1.15E−08 |
