Table 3 Genetic correlation of total cerebellar volume with (A) brain-based phenotypes and (B) brain-related phenotypes previously associated with cerebellar anatomy/function.

From: Genetic common variants associated with cerebellar volume and their overlap with mental disorders: a study on 33,265 individuals from the UK-Biobank

 

h2SNP (%)

h2SNP SE (%)

rg

95% Confidence intervals

p

pBonferroni

(A) Brain-based phenotypes

Brainstem

31.7

3.4

0.47

0.37

0.58

1.02E−18

1.02E−17

Pallidum

16.9

2.3

0.31

0.19

0.43

0.00000045

0.0000045

Thalamus

16.0

2.1

0.24

0.12

0.36

0.0000645

0.000645

Cortical surface area

35.3

3.2

−0.14

−0.25

−0.04

0.007

0.07

Amygdala

8.4

1.9

−0.18

−0.37

0.01

0.07

0.67

Hippocampus

13.0

2.7

−0.14

−0.29

0.02

0.08

0.84

Caudate

28.6

2.6

−0.07

−0.18

0.04

0.20

1.00

Accumbens

20.2

2.3

−0.07

−0.20

0.06

0.29

1.00

Putamen

28.6

2.8

0.01

−0.10

0.11

0.88

1.00

Cortical thickness

26.5

2.2

−0.01

−0.11

0.10

0.91

1.00

(B) Brain-related phenotypes

Schizophrenia disorder

42.1

1.5

−0.04

−0.10

0.02

0.18

0.90

Bipolar disorder

34.6

1.9

−0.04

−0.12

0.04

0.33

1.00

Attention Deficit Hyperactivity Disorder (ADHD)

22.7

1.7

−0.07

−0.17

0.03

0.18

0.90

Autism spectrum disorder (ASD)

19.5

1.5

−0.10

−0.22

0.02

0.10

0.50

Major Depressive Disorder

7.8

0.5

−0.02

−0.10

0.08

0.61

1.00

  1. h2SNP SNP-based heritability estimates (on the observed scale), SE standard error, rg genetic correlation, p uncorrected p values, pBonferronni p values adjusted for the number of tests performed regions/traits tested (10 and 6, respectively).
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