Fig. 3: Genes optimal for normal functioning of glutamate receptors, neuronal migration, and synapsis. | Molecular Psychiatry

Fig. 3: Genes optimal for normal functioning of glutamate receptors, neuronal migration, and synapsis.

From: Genetics of glutamate and its receptors in autism spectrum disorder

Fig. 3: Genes optimal for normal functioning of glutamate receptors, neuronal migration, and synapsis.The alternative text for this image may have been generated using AI.

Mutations or disruptions in genes optimal for neuronal migration, synapsis, and normal functioning of glutamate receptors can cause neuronal excitability, altered brain volume, and impaired long-term LTP and LTD that lead to various autism-related deficits. MZ marginal zone, CP cortical plate, IZ intermediate zone, SVZ subventricular zone, VZ ventricular zone, LTP long term potentiation, LTD long term depression.

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