Table 5 Structural responses to colchicine and dopamine in MDNCs from control individuals (CTL) versus patients with schizophrenia (SCZ).

From: Dopamine-induced pruning in monocyte-derived-neuronal-like cells (MDNCs) from patients with schizophrenia

Treatment

Structural Component Pruned

CTL

SCZ

P value

MEDa

P value

Control conditions

LPN (%)

5.8 ± 1.8

6.4 ± 1.6

0.81

5.3 ± 1.7

0.82

LSN (%)

−21.8 ± 4.4

−23.8 ± 3.6

0.73

−25.6 ± 4.1

0.55

# of Primaries

0.25 ± 0.07

0.27 ± 0.06

0.47

0.24 ± 0.07

0.57

# of Secondaries

0.51 ± 0.16

0.8 ± 0.13

0.19

0.66 ± 0.13

0.47

# of all neurites

0.77 ± 0.21

1.22 ± 0.17

0.12

1.04 ± 0.19

0.35

Colchicine 0.4 µM

LPN (%)

22.6 ± 10.3

19.2 ± 6.2

0.80

16.8 ± 7.0

0.69

LSN (%)

10.4 ± 5.9

14.5 ± 3.6

0.60

15.3 ± 3.8

0.51

# of Primaries

−0.08 ± 0.56

0.15 ± 0.07

0.27

0.18 ± 0.08

0.10

# of Secondaries

1.93 ± 0.61

1.09 ± 0.65

0.33

1.04 ± 0.41

0.33

# of all neurites

2.5 ± 0.74

1.2 ± 0.43

0.23

1.24 ± 0.53

0.30

Colchicine 0.5 µM

LPN (%)

20.1 ± 3.9

19.5 ± 2.5

0.90

17.7 ± 2.3

0.67

LSN (%)

15.8 ± 5.9

16.1 ± 3.7

0.97

16.6 ± 3.9

0.89

# of Primaries

0.023 ± 0.11

−0.027 ± 0.04

0.59

−0.038 ± 0.05

0.33

# of Secondaries

1.7 ± 0.38

1.6 ± 0.24

0.24

1.53 ± 0.24

0.63

# of all neurites

1.82 ± 0.53

1.80 ± 0.33

0.87

1.67 ± 0.35

0.80

Colchicine 0.75 µM

LPN (%)

23.6 ± 8.4

23.3 ± 5.3

0.97

19.0 ± 3.6

0.58

LSN (%)

11.0 ± 3.8

16.4 ± 2.4

0.30

15.1 ± 2.2

0.37

# of Primaries

−0.1 ± 0.17

0.11 ± 0.16

0.71

0.06 ± 0.17

0.81

# of Secondaries

1.5 ± 0.63

1.8 ± 0.39

0.72

1.63 ± 0.48

0.83

# of all neurites

1.7 ± 0.72

2.0 ± 0.46

0.77

1.81 ± 0.54

0.83

Dopamine 4 mM

LPN (%)

27.6 ± 8.7

23.6 ± 7.0

0.73

16.1 ± 6.3

0.23

LSN (%)

18.8 ± 6.3

20.9 ± 5.1

0.81

20.6 ± 5.4

0.93

# of Primaries

0.20 ± 0.10

0.16 ± 0.16

0.51

0.23 ± 0.16

0.51

# of Secondaries

1.6 ± 0.48

1.59 ± 0.38

0.89

1.52 ± 0.42

0.72

# of all neurites

2.08 ± 0.56

2.01 ± 0.45

0.93

1.96 ± 0.5

0.71

Dopamine 5 mM

LPN (%)

35.7 ± 10.8

22.8 ± 8.7

0.43

18.6 ± 9.7

0.31

LSN (%)

9.7 ± 26.4

25.4 ± 21.1

0.69

21.7 ± 24.6

0.78

# of Primaries

0.33 ± 0.10

0.27 ± 0.16

0.52

0.35 ± 0.17

0.05

# of Secondaries

2.96 ± 1.0

2.43 ± 0.88

0.74

2.33 ± 0.88

0.62

# of all neurites

3.53 ± 1.27

3.06 ± 1.02

0.80

3.06 ± 1.0

0.72

  1. aComparing only medicated patients (MED) versus CTL.
  2. LPN longest primary neurite, LSN longest secondary neurite.
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