Fig. 2: (Ultra-)rare variant enrichment in PI and brain cell gene sets. | Molecular Psychiatry

Fig. 2: (Ultra-)rare variant enrichment in PI and brain cell gene sets.

From: Ultra-rare and common genetic variant analysis converge to implicate negative selection and neuronal processes in the aetiology of schizophrenia

Fig. 2

Black stars denote significant gene-sets after multiple testing correction. ASC astrocytes, exCA1/exCA3 pyramidal neurons from the Hippocampal Cornu Ammonis regions, exDG granule neurons from the Hippocampal dentate gyrus region, exPFC1/exPFC2 pyramidal neurons from the prefrontal cortex, GABA1/GABA2 GABAergic interneurons. Although not included in the figure, the synaptic gene-sets were included in multiple testing correction. Regressions are corrected for sex, PCs and exome-wide (ultra)-rare PTV burden.

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