Fig. 2: The susceptible group reduced Rin and neuronal excitability in dorsal CA1 neurons, but not in ventral CA1 neurons. | Molecular Psychiatry

Fig. 2: The susceptible group reduced Rin and neuronal excitability in dorsal CA1 neurons, but not in ventral CA1 neurons.

From: Glucocorticoid-glucocorticoid receptor-HCN1 channels reduce neuronal excitability in dorsal hippocampal CA1 neurons

Fig. 2

A–J We performed whole-cell current-clamp recordings. A representative voltage responses with step current commands ranging from −150  pA to +30 pA (Δ = 20 pA) at RMP. B There was no difference in RMP of dorsal CA1 neurons between groups. C The dorsal CA1 neurons of the susceptible group had lower Rin at RMP than the control and resilient groups. D Representative voltage responses with depolarizing current step (210 pA; 750 ms) at RMP in dorsal CA1 neurons from the control, susceptible, and resilient groups. E Dorsal CA1 neurons from susceptible group had lower action potential firing than the control and resilient groups. F Representative voltage responses with step current commands ranging from −150 pA to +30 pA (Δ = 20 pA) at RMP. G, H There were no differences in RMP and Rin at RMP of ventral CA1 neurons between groups. I Representative voltage responses with depolarizing current step (210 pA; 750 ms) at RMP in the ventral CA1 neurons from the control, susceptible, and resilient groups. J Action potential firing of ventral CA1 neurons was not different between groups. Data are expressed as mean ± SEM.

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