Fig. 2: Comparison of neural layers found in development of the mammalian cerebral cortex.
From: Advancing preclinical models of psychiatric disorders with human brain organoid cultures
Simplified illustration of human, rodent, and organoid model systems expanding cortical neural layers, with cell types distinguished by color and morphology with legend on left. The human neural layers (left) are marked by an expanded subventricular zone with a unique outer layer, named the outer subventricular zone, where intermediate progenitors, outer radial glia, and migrating neuroblasts populate an expanding tissue layer, which will contribute to human neocortex. The corresponding neural tissue layers found in rodent developing cortex (middle) are depicted with analogous cell types and tissue layers labelled. Cortical organoid expanding neural cell layers include regions resembling the outer and inner subventricular zones termed ‘-like regions’ as they represent a model system rather than a fully functional characterized in vivo tissue. Illustration created with BioRender.com.
