Table 1 Demographics and key characteristics of participants by cognitive status.

From: Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease

 

CU

CI

P value

No.

75

46

–

Age, years

70.9 (5.8)

68.9 (7.6)

0.136

Male, No. (%)

28 (37.3)

25 (54.3)

0.101

Education, years

14.7 (3.4)

15.3 (3.1)

0.359

APOE ε4 carriers, No. (%)

22 (29.3)

26 (56.5)

0.006

MMSE score

29.1 (1.0)

25.2 (5.4)

<0.001

Neocortical Aβ-PET SUVR

1.51 (0.4)

2.20 (0.6)

<0.001

Temporal meta-ROI tau-PET SUVR

0.86 (0.1)

1.59 (0.8)

<0.001

Hippocampal volume, cm3

3.53 (0.4)a

3.16 (0.5)a

<0.001

  1. Continuous variables are presented as mean (SD).
  2. Aβ amyloid-β, APOE ε4 Apolipoprotein E ε4, CI cognitively impaired, CU cognitively unimpaired, MMSE Mini-Mental State Examination, PET positron emission tomography, ROI region of interest, SD standard deviation, SUVR standardized uptake value ratio.
  3. aValues reported are adjusted for total intracranial volume.
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