Fig. 5: Association of dorDG and venDG cell types with master regulators and cellular cross-talks. | Molecular Psychiatry

Fig. 5: Association of dorDG and venDG cell types with master regulators and cellular cross-talks.

From: Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling

Fig. 5: Association of dorDG and venDG cell types with master regulators and cellular cross-talks.

a Heatmap of differentially active regulons identified by SCENIC in dorDG cell types, coloured by fold-change of regulon activity score in FT vs sham. Blue rectangle indicates regulons related to energy metabolism. Bold indicates the top differential regulon for major cell types. b As in a, but for venDG. c. NATMI-identified differential ligand-receptor pairs in dorDG cell types between FT and Sham. Top differential interactions (by higher specificity score and greater difference in specificity score) are labelled. d As in b, but for venDG.

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