Fig. 6: Schematic summary of effects of chronic fluoxetine identified in this study. | Molecular Psychiatry

Fig. 6: Schematic summary of effects of chronic fluoxetine identified in this study.

From: Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling

Fig. 6: Schematic summary of effects of chronic fluoxetine identified in this study.

1. Broad effects of chronic fluoxetine: Enriched functional terms and overarching pathways. 2. DEGs across brain regions showed significant enrichment for MDD associated gene loci. A network diagram for 4 regions and their respective MDD-DEGs are illustrated. Region specific downstream pathways and functional implications are shown. Red – upregulated gene, green- downregulated gene; Orange terms indicate upregulated functional activity, while blue denotes inhibition of the functional term. 3. Fluoxetine-induced effects at single-cell resolution.

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