Fig. 2: The effect of genotype, sex and citalopram plasma concentrtion on serotonin transporter occupancy.
From: ABCB1 variants and sex affect serotonin transporter occupancy in the brain
a Approximately one hour after infusion of 8 mg citalopram, lower serotonin transporter occupancy was observed in ABCB1rs2235015 minor allele carriers (A + AC) compared to major allele homozygotes (C) and female compared to male participants. b SERT occupancy is plotted against the area under the curve (AUC) of citalopram in plasma. Regression lines are plotted for participants grouped according to ABCB1rs2235015 genotype. Grey ribbons indicate 95% confidence intervals.
