Fig. 2: Effects of Aβ1-6A2V(D) on brain levels of Aβ monomers and oligomers. | Molecular Psychiatry

Fig. 2: Effects of Aβ1-6A2V(D) on brain levels of Aβ monomers and oligomers.

From: A novel bio-inspired strategy to prevent amyloidogenesis and synaptic damage in Alzheimer’s disease

Fig. 2: Effects of Aβ1-6A2V(D) on brain levels of Aβ monomers and oligomers.

Biochemical study on APPSwe/PS1dE9 mice intranasally treated with Aβ1-6A2V(D) every 48 h for 5 months. Aβ40, Aβ42 and aggregated Aβ levels were measured by ELISA in soluble and insoluble fractions of brain homogenates from mice treated with saline solution (blue columns, control group, n = 10) or Aβ1-6A2V(D) (red columns, n = 10). Aggregated Aβ levels were significantly reduced in soluble (*** p = 0.0005) and insoluble (* p = 0.04) fractions of animals treated with Aβ1-6A2V(D) compared to controls.

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