Fig. 2: Group statistics and relationship between functional and structural locus coeruleus (LC) connectivity.

Regions with high structural connectivity (a, DTI) are also strongly functionally (a, fc) connected to the LC (FDR p < 0.05), most evident in the subcortical thalamic, ventral diencephalic, cerebellar regions and the presubiculum (regions counter-clockwise ordered by strongest structural and functional connections, see also Supplementary Table 3 for Glasser abbreviations). In (b), colors and opacity illustrate group statistics of strength of functional (left column, group level FDR p < 0.05, h-values) and structural connectivity (DTI, right column, group level FDR p < 0.05, F values) to the whole brain, with blue colored regions representing strongest connectivity.