Table 1 Patient information, grouped by different neuronal cell surface antibodies (n = 143).

From: The serum metabolomic profile of a distinct, inflammatory subtype of acute psychosis

 

Ab negative (Ctrl)

Ab positive

GlyR-Ab

VGKC-Ab

CASPR2-Ab

LGI1-Ab

NMDAR-Ab

Number of patients

70

73

7

13

9

9

35

Age (years), median (IQR)

27 (15)

25 (13)

24 (10)

23 (8)

24 (11.5)

25 (15)

32 (18)

Gender, Female, no. (%)

31 (44.3)

30 (41.1)

4 (57.1)

5 (38.5)

3 (33.3)

1 (11.1)

17 (48.6)

Ethnicity (%)

   White

71.4

67.1

100

61.5

55.6

77.8

62.9

   Asian

12.9

12.3

0

0

22.2

11.1

17.1

   Black (African/Caribbean)

7.1

9.5

0

23.1

11.1

11.1

5.7

   Mixed

4.3

6.8

0

7.7

11.1

0

8.6

   Other

4.3

0

0

0

0

0

0

   Unknown

0

4.1

0

7.7

0

0

5.7

Disease duration (duration from the episode date to the consent date, days), median (IQR)

86 (258.8)

103 (244.5)

267 (399)

37 (23)

230 (317)

132 (404)

113 (229)

   Unknown, no.

0

4

2

1

0

1

0

Episode type, no. (%)

   First episode

45 (64.3)

50 (68.5)

7 (100)

13 (100) (adjusted p value = 0.51)

6 (66.7)

7 (77.8)

17 (48.57)

   Relapse

24 (34.3)

22 (30.1)

0 (0)

0 (0)

3 (33.3)

1 (11.1)

18 (51.4)

   Unknown

1 (1.4)

1 (1.4)

0 (0)

0 (0)

0 (0)

1 (11.1)

0 (0)

PANSS

   Total score, median (IQR)

12 (6)

14 (8.8)

19 (6)

23 (12.5)**

11 (8.5)

12 (4.5)

13 (7)

   Unknown, no.

0

0

1

0

0

0

0

  1. The Kruskal-Wallis test with Dunn’s multiple comparisons test was used to identify significant differences of each class compared to Control for numerical variables (age, PANSS scores) while Fisher’s exact test was used for categorical variables. Ethnicity data was analysed by comparing White vs Combined Asian/Black/Mixed/Other ethnic groups in Ctrl, combined VGKC/GlyR Group, combine NMDAR/LGI1/CASPR2 Group, as applicable to Chi-square test/Fisher’s exact test. **p < 0.01.
  2. Ctrl control, psychosis patients tested negative for the following neuronal cell surface antibodies. Ab antibody, psychosis patients tested positive for one of the following neuronal cell surface antibodies. GlyR glycine receptor. VGKC voltage-gated potassium channel complex. CASPR2 contactin associated protein-like 2. LGI1 leucine-rich glioma inactivated 1. NMDAR N-methyl-D-aspartate receptor. PANSS Positive and Negative Syndrome Scale. IQR Interquartile Range.