Table 2 Comparison of PANSS scores of patients with VGKC/GlyR antibody, NMDAR/LGI1/CASPR2 antibody test, and antibody negative control groups.

From: The serum metabolomic profile of a distinct, inflammatory subtype of acute psychosis

 

Ctrl

VGKC/GlyR

NMDAR/LGI1/CASPR2

Number of patients

70

19

53

Age (years), Median (IQR)

27 (15)

23 (8)

28 (15)

Gender, Female, no. (%)

31 (44.3)

8 (42.1)

21 (39.6)

PANSS, Median (IQR)

   Positive symptom score

6 (2.3)

9 (5)*

7 (3)

   Negative symptom score

3 (3)

6 (6)*

3 (3)

   General symptom score

2 (0)

5 (5)***

2 (0)†††

   Total score

12 (6)

19 (8)***

12 (6)†††

  1. The PANSS score for one VGKC/GlyR patient was not available and so was excluded from this table.
  2. The Kruskal-Wallis test with Dunn’s multiple comparisons test was used to identify significant differences of each class for numerical variables (age, PANSS scores) while Fisher’s exact test was used for categorical variables. *Indicates significant differences of each class compared to Ctrl. †indicates significant differences of each class compared to VGKC/GlyR. *p < 0.05, ***p < 0.001. †††p < 0.001.
  3. Ctrl control, psychosis patients tested negative for the following neuronal cell surface antibodies. VGKC/GlyR voltage-gated potassium channel complex & glycine receptor; psychosis patients tested positive for either antigen. CASPR2 contactin-associated protein-like 2; LGI1 leucine-rich glioma inactivated 1, NMDAR N-methyl-D-aspartate receptor. NMDAR/LGI1/CASPR2 psychosis patients tested positive for CASPR2/LGI1/NMDAR. PANSS Positive and Negative Syndrome Scale. IQR Interquartile Range.
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