Table 1 Summary of cohorts used in this study.

From: Genome-wide association study meta-analysis of suicide death and suicidal behavior

 

Cohorts 1 and 2

Cohort 3 (PsychArray)

Cohort 4 (Omni1Mc)

Cohort 5

 

Affection status

Casesa

Cases

Controlsb

Cases

Controlsb

Cases

Controlsb

Case phenotype

Suicide death

Suicidal attempts

 

Suicidal attempts

 

Suicidal attempts

 

N

3765

183

1199

268

780

4098

247,898

Cases with linked demographic data, N

3426

183

1199

268

780

4098

247,898

Cases with linked demographic data and EHR, N

2981

N/A

N/A

N/A

N/A

4098

247,898

Demographic information

Female, n (%)

743 (21.7)

95 (51.9)

612 (51.0)

142 (53.0)

435 (55.8)

3525 (86.0)

138,666 (55.9)

Age, mean (SD)

41.0 (17.2)

47.1 (13.0)

44.3 (14.2)

41.2 (11.8)

43.6 (12.5)

56.6 (17.8)

59.6 (17.7)

Clinical characteristics, n (%)

Bipolar disorder

321 (10.8)

  

91 (34.0)

223 (28.6)

257 (6.3)

3428 (1.4)

Broad bipolar spectrum illness

450 (15.1)

    

295 (7.2)

4130 (1.7)

MDD

927 (31.1)

87 (47.3)

492 (41.0)

93 (34.7)

355 (45.5)

1020 (24.9)

20,691 (8.3)

Broad depression

1568 (52.6)

    

1141 (27.8)

24,379 (9.8)

Anxiety

747 (25.1)

    

844 (20.6)

17,576 (7.1)

Schizophrenia

117 (3.9)

53 (28.8)

579 (48.3)

20 (7.5)

87 (11.2)

222 (5.4)

2634 (1.1)

Psychosis

295 (9.9)

    

673 (16.4)

13,185 (5.3)

Pain

1636 (54.9)

    

40 (1.0)

1012 (0.4)

Sleep problems

822 (27.6)

    

328 (8.0)

9312 (3.8)

SUD

1513 (50.8)

    

739 (18.0)

13,895 (5.6)

SLE

283 (9.5)

    

–

–

Suicidal ideation

560 (18.8)

    

–

–

Adult maltreatment

7 (0.2)

    

–

–

Childhood maltreatment

15 (0.5)

    

–

–

Any mental health

2142 (71.9)

    

2378 (58.0)

73,576 (29.7)

Diabetes

278 (9.3)

      

Asthma

359 (12.0)

      

Schizoaffective disorder

 

43 (23.5)

128 (10.7)

64 (23.9)

115 4.7)

  
  1. Specifically, cohorts 1 and 2 are used for suicide death (SD) GWAS meta-analysis, and cohorts 1–5 are used for suicidal behavior (SB) GWAS meta-analysis.
  2. aThe controls for cohort 1 are Coriell controls screened for psychiatric medical and family history (n = 804), while the controls for cohort 2 are IAMDGC controls not screened for suicide attempt (n = 5768).
  3. bThe controls for cohorts 3 and 4 are psychiatric controls within the same studies.
  4. cUsing the overlapping markers between Omni1M-Duo and Omni5M.
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