Table 3 Replication results for genome-wide significant loci identified in the ISGC and MVP meta-analysis.

From: Genome-wide association study meta-analysis of suicide death and suicidal behavior

CHR

SNP

BP

A1

A2

FRQ_A_4098

FRQ_U_247898

INFO

OR

SE

p

Nearest gene (distance to index SNP in kb)

1

rs3791129

44,480,093

A

G

0.7582

0.7503

0.99

1.06

0.03

0.041

SLC6A9 (0.0)

1

rs2503185

66,461,401

G

A

0.4231

0.4347

1

0.96

0.02

0.078

PDE4B (0.0)

11

rs7131627

113,299,829

A

G

0.4986

0.5107

1

0.96

0.02

0.075

DRD2 (0.0)

12

rs17485141

24,213,634

T

C

0.2325

0.248

1

0.92

0.03

0.003

SOX5 (0.0)

13

rs9525171

96,908,223

G

C

0.4996

0.5072

1

0.97

0.02

0.259

HS6ST3 (0.0)

14

rs850261

57,346,423

G

A

0.4344

0.4274

1

1.04

0.02

0.114

OTX2-AS1 (0.0)

15

rs17514846

91,416,550

A

C

0.3905

0.3936

1

0.99

0.02

0.59

FURIN (0.0)

22

rs2284000

37,053,338

G

C

0.2922

0.2902

0.99

1

0.03

0.853

CACNG2 (0.0)

3

rs7649709

173,129,819

A

C

0.3291

0.3269

0.96

1

0.02

0.965

NLGN1 (0.0)

6

rs62404522

19,307,114

C

T

0.1416

0.1301

1

1.12

0.03

0.001

LOC101928519 (–76.4)

6

rs35869525

26,946,687

T

C

0.04866

0.05079

1

0.98

0.05

0.642

MHC

7

rs62474683

115,020,725

G

A

0.4203

0.4283

1

0.97

0.02

0.172

LINC01392 (–149.3)

  1. A1: Allele 1 (odds ratios calculated with respect to this allele), A2: Allele 2, INFO: quality of imputation for the SNP.
  2. BP base-pair position in reference to hg19, CHR chromosome, FRQ_A minor allele frequency (A1) in cases, FRQ_U minor allele frequency (A1) in controls, OR odds ratio, SE standard error, SNP single-nucleotide polymorphism.
  3. P-values in bold signify replication with consistent directional effects.