Table 5 Results of multiple regression analyses with clinical measurements as dependent variables and oxidative stress toxicity (OSTOX) and antioxidant (ANTIOX) biomarkers as explanatory variables.

Regression	Explanatory variables	β	t	p	F model	df	p	R²
#1. Depression HAMD	Model				23.16	5/150	<0.001	0.441
	Body temperature	0.390	5.12	<0.001
	OSTOX	2.37	3.70	<0.001
	SpO2	−0.195	−2.49	0.014
	Education	−0.161	−2.59	0.011
	Age	−0.137	−2.21	0.028
#2. Somatic HAMD	Model				30.59	4/151	<0.001	0.448
	SpO2	−0.427	−5.48	<0.001
	Body temperature	0.238	3.14	0.002
	Astra + Pfizer	0.158	2.57	0.011
	NO	0.149	2.41	0.017
#3. Depression HAMA	Model				26.14	3/152	<0.001	0.340
	SpO2	−0.511	−7.64	<0.001
	Female sex	0.223	−3.38	<0.001
	Astra + Pfizer	0.133	1.99	0.048
#4. Somatic HAMA	Model				41.14	5/150	<0.001	0.578
	SpO2	−0.533	−7.78	<0.001
	Body temperature	0.241	3.61	<0.001
	Astra + Pfizer	−0.134	2.50	0.014
	NO	0.123	2.27	0.025
	Femal sex	−0.114	−2.13	0.035
#5. Somatic FF	Model				53.60	4/151	<0.001	0.587
	SpO2	−0.457	−6.84	<0.001
	Body temperature	0.322	4.95	<0.001
	NO	0.151	2.80	0.006
	MDA	0.132	2.49	0.014
#6. Neuropsychiatric symptoms score	Model				59.77	4/151	<0.001	0.613
	SpO2	−0.531	−8.02	<0.001
	Body temperature	0.246	3.90	<0.001
	OSTOX/ANTIOX	0.151	2.73	0.007
	Female sex	0.111	2.19	0.030
#7. OSTOX/ANTIOX	Model				30.26	1/154	<0.001	0.164
#7. OSTOX/ANTIOX	SpO2	−0.405	−5.50	<0.001	30.26	1/154	<0.001	0.164
#9. CRP	Model				46.14	2/153	<0.001	0.376
	Body Temperature	0.568	8.90	<0.001
	Male sex	0.245	3.83	<0.001

These regression analyses are performed in patients and controls combined.
Gpx Glutathione peroxidase, MDA malondialdehyde, NO nitric oxide, SpO2 peripheral oxygen saturation, FF Fibro-Fatigue scale, HAMD Hamilton Depression Rating scale, HAMA Hamilton Anxiety Rating scale, Astra + Pfizer vaccination with either AstraZeneca or Pfizer-BioNTech (versus Sinopharm S), CRP C-reactive protein.

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