Fig. 1: Chemical structures and inhibition of transporter-mediated uptake by cathinones.
From: Serotonin-releasing agents with reduced off-target effects
a–e display the synthesis and the chemical structures of the stereoisomers of MC, 4-MMC, 4-MC and 4-TFMMC, respectively. f–i display inhibition of human DAT-mediated uptake of [3H]MPP+ and j–m depict inhibition of [3H]5-HT transport via human SERT in HEK293 cells. Data are shown as mean and standard deviation. N > 3 independent experiments. Detailed sample sizes are given in the Supplementary Information.
