Fig. 3: GluA1 deletion disrupts within-session habituation of light cue evoked DA responses. | Molecular Psychiatry

Fig. 3: GluA1 deletion disrupts within-session habituation of light cue evoked DA responses.

From: Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience

Fig. 3

Average DA release to the LED light cue separated into the first (Early) and second (Late) half of the session to assess stimulus habituation. a Pictorial representation of relevant task parameters, assessing DA release in response to presentations of the LED light stimulus early and late in the session. b WT mice show significant habituation of DA responses to the LED. * Simple effects revealed significant differences at 1–4 s into stimulus presentation, F1, 15.00 = 16.29, p = 0.001, F1, 15.50 = 12.90, p = 0.003, F1, 20.06 = 6.71, p = 0.017, F1, 24.27 = 4.38, p = 0.047, respectively. c Gria1−/− mice do not show habituation of DA responses to the LED. Inset bar graphs depict the peak DA estimated at 1 s post stimulus onset. All error bars represent ± standard error of the mean.

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