Fig. 1: Transdiagnostic Composition of the HYDRA-identified Subtypes of Mood and Anxiety Disorders in Pre-adolescents.

The figure illustrates the composition of each cluster in terms of traditional clinical diagnoses. Chi-squared tests revealed that subtype 1 (N = 631) and subtype 2 (N = 649) had equal proportions of participants with mood and anxiety disorders (χ2 = 2.45, P = 0.48), and subtype 3 (N = 651) had more participants with bipolar disorders, and fewer participants with anxiety disorders relative to subtype 1 (χ2 = 15.80, P = 0.001) and subtype 2 (χ2 = 10.12, P = 0.02).