Fig. 4: Correlation matrices of brain regions involved in contextual fear learning. | Molecular Psychiatry

Fig. 4: Correlation matrices of brain regions involved in contextual fear learning.

From: Age, sex, and apolipoprotein E isoform alter contextual fear learning, neuronal activation, and baseline DNA damage in the hippocampus

Fig. 4: Correlation matrices of brain regions involved in contextual fear learning.

Pearson’s correlations were run for (A) E2, (B) E3, and (C) E4 mice to identify co-activation of cFos immunoreactivity across regions. Comparison of the correlation matrices revealed that E4 mice were different from E3 mice (p = 0.0174, \(\hat T\) = 3.9302). To identify the drivers of this difference, we mapped the regions that had r values > 0.7 or < −0.7 and generated chord diagrams for (D) E2, (E) E3, and (F) E4 animals. G A Venn diagram of the number of regions that were identified as having the strongest correlations in each of the genotypes, and their overlap.

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