Table 3 Meta-regression between baseline prevalence of comorbid mental disorders in CHR-P individuals and transition to psychosis at follow-up.

Outcome	Coefficient	SE	P value	N of studies	Follow-up, mean^a	Follow-up, SD
Any mood disorder	−0.27	0.05	0.01	31	30.72	22.43
GAD	−1.01	0.47	0.03	15	36.54	36.24
Agoraphobia	−2.38	0.95	0.01	10	27.69	33.56
Dysthymia	0.73	0.92	0.43	15	39.21	36.71
Somatoform disorder	0.62	1.24	0.62	17	38.83	35.93
Adjustment disorder	0.42	0.82	0.61	13	29.01	16.13
Any personality disorder	0.19	0.18	0.29	12	18.96	9.427
Scizotypal personality disorder	0.15	0.32	0.64	17	29.94	24.07
PTSD	0.14	0.32	0.65	15	29.79	25.72
Any depressive disorder/episode	0.11	0.13	0.40	25	33.81	28.04
Other disorders NOS	0.10	0.72	0.89	13	24.86	17.41
Cannabis use disorder	0.05	0.32	0.88	11	28.86	14.81
Alcohol use disorder	0.03	0.31	0.91	11	28.31	18.15
Any non-psychotic mental disorder	0.03	0.18	0.88	15	31.52	21.82
Any substance use disorder	0.02	0.16	0.89	26	28.52	22.10
Panic disorders	−0.08	0.46	0.86	17	35.77	34.04
Major depressive disorder	−0.12	0.14	0.40	20	32.03	32.48
Any anxiety disorder	−0.12	0.08	0.14	42	24.02	17.24
Social anxiety disorder (or social phobia)	−0.13	0.46	0.78	15	27.17	16.22
Borderline personality disorder	−0.17	0.21	0.40	12	41.95	38.88
OCD	−0.42	0.36	0.24	25	28.56	25.93
Any eating disorder	−0.67	0.69	0.33	20	28.71	27.60
Specific phobia	−0.99	0.82	0.23	11	33.24	33.70
Other bipolar disorder (e.g. BD-NOS, BD-II)	−1.02	0.96	0.29	20	34.94	28.48

ADHD attention-deficit/hyperactivity disorder, BD bipolar disorder, CHR-P clinical high risk for psychosis, GAD generalized anxiety disorder, NOS not otherwise specified, OCD obsessive-copulsive disorder, PTSD post-traumatic stress disorder, SD standard deviation, SE standard error.
^aMonths.

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