Table 1 Demographic, clinical, and psychological characteristics of the population.

From: Resilience to substance use disorder following childhood maltreatment: association with peripheral biomarkers of endocannabinoid function and neural indices of emotion regulation

 

CM with SUD

CM only

SUD only

Control

p-value

 

N = 28

N = 24

N = 25

N = 24

 

Sex: Female

15 (54%)

17 (71%)

12 (48%)

13 (54%)

0.41

Age

28.9 (3.5)

28.9 (3.9)

27.5 (3.3)

28.3 (5.2)

0.56

Education

    

<0.001

Elementary school

5 (18%)

1 (4%)

6 (24%)

0 (0%)

 

Vocational education

14 (50%)

13 (54%)

11 (44%)

1 (4%)

 

High school

4 (14%)

1 (4%)

4 (16%)

2 (8%)

 

University

4 (14%)

7 (29%)

4 (16%)

21 (88%)

 

Born in Sweden

22 (79%)

15 (63%)

18 (72%)

18 (75%)

0.38

Current psychiatric diagnosis (MINI)1

23 (82%)

9 (38%)

20 (80%)

1 (4%)

<0.001

Psychotropic medication2

13 (46%)

4 (17%)

15 (60%)

3 (13%)

<0.001

Current SUD/AUD (MINI)

13 (46%)

0 (0%)

10 (40%)

0 (0%)

<0.001

Current SUD (MINI)

6 (21%)

0 (0%)

3 (11%)

0 (0%)

=0.003

Current AUD (MINI)

11 (39%)

0 (0%)

8 (28%)

0 (0%)

<0.001

AUDIT

8.2 (5.7)

4.3 (2.6)

6.3 (6.2)

3.9 (3.4)

0.005

DUDIT

3.8 (7.4)

0.1 (0.4)

6.2 (7.9)

.0 (.0)

<0.001

CPRS total scores

15.5 (9.0)

9.4 (7.1)

12.3 (7.4)

4.3 (3.8)

<0.001

CPRS Depression scores (MADRS)

8.1 (4.7)

4.0 (3.7)

5.7 (4.1)

1.7 (1.8)

<0.001

CPRS_Anxiety

7.9 (4.9)

5.8 (3.9)

7.0 (3.6)

3.0 (2.4)

<0.001

DERS total Scores

43.1 (16.4)

34.8 (14.2)

40.6 (15.1)

25.9 (7.3)

<0.001

CTQ Scores

Total score

50.3 (19.8)

51.5 (18.9)

42.6 (16.1)

28.3 (3.9)

<0.001

Physical abuse

9.4 (4.8)

8.7 (3.9)

6.6 (2.9)

5.1 (.3)

<0.001

Sexual abuse

8.4 (5.5)

9.8 (6.6)

5.2 (.7)

5.0 (.0)

<0.001

Emotional abuse

12.1 (5.7)

11.6 (5.4)

10.7 (5.4)

5.7 (1.0)

<0.001

Physical neglect

8.3 (3.0)

8.9 (4.4)

8.4 (4.6)

5.3 (.7)

0.003

Emotional neglect

12.1 (5.7)

12.5 (4.7)

11.6 (5.5)

7.2 (2.9)

<0.001

ADHD TOTAL scores (MINI)

7.6 (5.1)

3.9 (3.6)

7.6 (5.5)

1.6 (1.7)

<0.001

MRI session

N = 25

N = 22

N = 23

N = 24

 

Task Behavior3 - Accuracy (RT)

N = 22 (24)

N = 22 (22)

N = 20 (21)

N = 23 (24)

 

Task-based fMRI analysis3

N = 25

N = 22

N = 22

N = 24

 

Task-based fMRI analysis4

N = 25

N = 22

N = 21

N = 24

 

Resting state fMRI analysis

N = 23

N = 22

N = 23

N = 23

 
  1. Data are presented as mean (SD) for continuous measures, and n (%) for categorical measures. Between-group differences in sociodemographic scores were driven by the healthy controls group. 1ongoing psychiatric diagnosis according to MINI screening; 2stable standard doses for at least three months of common psychotropic medications; 3Emotional Conflict Task; 4Negative Affect Picture Task; SUD substance use disorder, current diagnosis according to MINI interview, AUDIT Alcohol Use Disorders Identification Test, DUDIT Drug Use Disorders Identification Test, CPRS Comprehensive Psychopathological Rating Scale, self-report, DERS Difficulties in Emotion Regulation Scale, NEO Neuroticisms=NEO Five-Factor Inventory, Neuroticism; CTQ childhood trauma questionnaire, ADHD total number of symptoms from the inattentive and hyperactive impulsive subscales.
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