Fig. 3: Correlation matrix with multiple correction to investigate the regulation of the various genes between pathways, under DMSO or tBHQ conditions, and in the response to tBHQ.

A Schematic representation of the color meaning for DMSO or tBHQ conditions, and in the response to tBHQ. Each gene was correlated to all the others in the DMSO and tBHQ condition separately, highlighted by the blue color when the correlation is negative and red when it is positive. Two genes can be negatively correlated under DMSO condition, but positively correlated under tBHQ treatment. In order to evaluate the response to tBHQ, correlations between genes were also investigated by looking at the correlation of the values of DMSO and tBHQ on the same graph. When tBHQ induced an upregulation of the two genes, the correlation was positive (red), while the correlation was negative (blue) when tBHQ induced a downregulation. Correlation matrix for the 4 groups, namely B the GAG-gclc- LR controls (LR CT), C HR controls (HR CT), D LR patients (LR PA) and E HR patients (HR PA). All groups show a different correlation profile, suggesting some regulatory processes related to the GAG-gclc HR polymorphism in patients, other risk factors in LR patients, but also protective mechanism in the HR controls.