Fig. 4: Discriminant analysis to compare two-by-two the different groups under DMSO and tBHQ conditions. | Molecular Psychiatry

Fig. 4: Discriminant analysis to compare two-by-two the different groups under DMSO and tBHQ conditions.

From: Characterization of early psychosis patients carrying a genetic vulnerability to redox dysregulation: a computational analysis of mechanism-based gene expression profile in fibroblasts

Fig. 4: Discriminant analysis to compare two-by-two the different groups under DMSO and tBHQ conditions.

A Discriminant analysis on GAG-gclc LR patients (LR PA) and controls (LR CT) to identify pathways that would differentiate between patients and controls, independently of the GAG-gclc risk. B Discriminant analysis on GAG-gclc HR patients (HR PA) and controls (HR CT) to identify potential protective pathways, but also highlight pathways induced by other risks in interaction with the GAG-gclc polymorphism that would lead to the disease. C Discriminant analysis on GAG-gclc LR (LR CT) and HR (HR CT) controls to investigate the potential protective mechanism in the controls bearing the GAG-gclc polymorphism. D Discriminant analysis on GAG-gclc LR (LR PA) and HR (HR PA) patients to point out the pathways related to the GAG-gclc risk, but also to reveal some pathways related to other risks, in order to stratify sub-groups of patients. Genes that are contributing the most to the discrimination are showed in the corresponding tables.

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