Table 1 Sequences and details of the Chop ASOs.

From: Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD

ASO ID

Sequences

Effects

Chemical modifications

Reference

ASO#3*

CTAGATCCTTTCTAACTCCT

Knockdown of  Chop gene

Central gap segment containing ten 2′- deoxyribonucleotides flanked at 5′ and 3′ with 2’MOE modified nucleotides; linkages with phosphodiester; all cytosines are 5′-methylcytosines.

[20, 22]

ASO#5

GATGCAATTTTTTATTTTTC

N/A

  
  1. *indicates that ASO#3 was used in the experiments in this study.
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