Table 2 Genes showing statistical significant difference with >2-fold change in cortex of rNLS8 mice at 2 weeks or 4 weeks off Dox compared to controls detected on RT2 PCR array.

From: Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD

Symbol

Unigene

Refseq

Description

2 weeks off Dox

4 weeks off Dox

Fold change relative to control mice

p-value

Fold change relative to control mice

p-value

Atf4

Mm.641

NM_009716

Activating transcription factor 4

4.6

0.01870

2.5

0.01253

Bid

Mm.235081

NM_007544

BH3 interacting domain death agonist

2.6

0.00004

2.6

0.00112

Ccl12

Mm.867

NM_011331

Chemokine (C-C motif) ligand 12

15.5

0.01318

8.4

0.05732

Crp

Mm.28767

NM_007768

C-reactive protein, pentraxin-related

1.4

0.28464

2.9

0.00051

Chop

Mm.110220

NM_007837

DNA-damage inducible transcript 3

2.3

0.01857

1.7

0.10291

Gadd45g

Mm.281298

NM_011817

Growth arrest and DNA-damage-inducible 45 gamma

2.7

0.03883

1.8

0.00933

Hmox1

Mm.276389

NM_010442

Heme oxygenase (decycling) 1

2.4

0.01609

2.3

0.08352

Il6

Mm.1019

NM_001314054

Interleukin 6

6.8

0.01527

5.6

0.00768

Ldha

Mm.29324

NM_010699

Lactate dehydrogenase A

0.7

0.00539

0.5

0.00066

Slc9a3

Mm.261564

NM_001081060

Solute carrier family 9 (sodium/hydrogen exchanger), member 3

0.6

0.05494

0.5

0.00415

Tlr4

Mm.38049

NM_021297

Toll-like receptor 4

1.4

0.02000

2.1

0.04270

Tnf

Mm.1293

NM_013693

Tumor necrosis factor

7.5

0.00347

9.0

0.01730

Trp53

Mm.222

NM_011640

Transformation related protein 53

2.4

0.04958

1.6

0.00374

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