Fig. 5: Elevated levels of mitochondrial superoxide in AS NPCs. | Molecular Psychiatry

Fig. 5: Elevated levels of mitochondrial superoxide in AS NPCs.

From: Elevated ROS levels during the early development of Angelman syndrome alter the apoptotic capacity of the developing neural precursor cells

Fig. 5

A A Representative FACS-derived histogram of the MitoSOX fluorescence intensity, measuring the mitochondrial superoxide levels of WT and AS cultured NPCs. The dashed vertical line depicts the threshold for “high” MitoSOX fluorescence (see C). B AS NPCs show a higher mean fluorescence intensity (MFI) of MitoSOX than WT NPCs. C AS NPCs consist a higher percentage of cells with high fluorescence intensity of MitoSOX. N  =  4 for each group. For all panels, data are presented in means ± SEM (*p < 0.05 in t-test).

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