Table 1 Distinct organization of the resting-state Functional Connectivity of five groups of subjects and their associated temperament, character, and clinical features.
Functional Type (clinical) | rsFC Network | Group 1 Avoidant-Anhedonic | Group 2 Sensitive- Disorganized | Group 3 Asocial- Blocked | Group 4 Fragile-Avolitional | Group 5 Explosive -Inattentive |
|---|---|---|---|---|---|---|
PFC top-down | Default Mode | Positive | Positive | Negative | Negative | Negative |
Cingulo-Opercular | Positive | Positive | Positive | Negative | Negative | |
Fronto-Parietal | Positive | Positive | Positive | Positive | Positive | |
Dorsal Attention | Positive | Positive | Positive | Positive | Negative | |
self-regulatory functioning/ character | Defensive Control (s) | Overattentive Schizotype (scT) | Hostility Mistrust (cT) | Avolition Apathy (s) | Inattentive Schizotype (scT) | |
PFC Bottom-up | Ventral Attention | Positive | Positive | Negative | Negative | Negative |
Salience | -- | Positive | -- | -- | -- | |
emotional reactivity/ temperament | Harm Avoidance (H) | Ambivalence (HN) | Novelty Seeking (N) | Fragility (pHN) | Explosive Borderline (rHN) | |
Automated modules | Visual | Positive | Positive | Negative | Negative | Negative |
Auditory | -- | Positive | Positive | Negative | -- | |
Thalamus | -- | -- | Positive | Negative | -- | |
Striatum | -- | Positive | Positive | Negative | -- | |
Context | -- | -- | Positive | -- | Negative | |
Perception | -- | Positive | Positive | Positive | Negative | |
SM hand | -- | Positive | Positive | Negative | Negative | |
SM mouth | -- | Positive | Negative | Negative | Positive | |
Amygdala | -- | -- | -- | -- | -- | |
Entorhinal | -- | -- | -- | -- | -- | |
(Negative sx) | Anhedonia Asociality | Alogia Blunt Affect | Blocking | Avolition Apathy | Inattention | |
(Positive sx) | -- | Bizarre behavior Thought disorder | Somatic Delusions | Hallucinate Delusions | -- |
