Table 1 Agonist affinities at α2-AR subtypes.

From: Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders

Agonist

α2A-AR

α2B-AR

α2c-AR

Kd (nM)a

 clonidine

73–84

71

81

 dexmeditomidine

18

31

nd

 guanfacine

14–31

1850

421

Ki (nM)b

 clonidine

43

106

233

 dexmeditomidine

6

18

38

 guanfacine

72

1200

2505

  1. afrom references [114, 115].
  2. bfrom https://en.wikipedia.org/wiki/Alpha-2_adrenergic_receptor citing the following database: Roth BL, Dricol J, PDSP Ki Database:
  3. https://web.archive.org/web/20131108013656/http://pdsp.med.unc.edu/pdsp.php
  4. nd not done
Back to article page